JG-98 |CAS:1456551-16-8 Probechem Biochemicals

Chemical Structure : JG-98

CAS No.: 1456551-16-8

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JG-98 (JG98)

货号: PC-62492Not For Human Use, Lab Use Only.

JG-98 is an allosteric Hsp70 inhibitor, displays >3-fold more active, greater stability than MKT-077 against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50 of 0.4 uM and 0.7 uM, respectively).

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5 mg	￥1880	In stock
10 mg	￥2980	In stock
25 mg	￥4880	In stock
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100 mg		Get quote

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生物&药学活性

JG-98 is an allosteric Hsp70 inhibitor, displays >3-fold more active, greater stability than MKT-077 against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50 of 0.4 uM and 0.7 uM, respectively).
JG-98 strongly affects autophagic flux, increases p62 oligomerization and reduces p62 monomer.
JG-98 destabilizes FoxM1 and relieved suppression of downstream effectors, including p21 and p27.

物理化学性质&存储条件

分子量	534.532
分子式	C24H21Cl2N3OS3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Thiazolium,2-[(Z)-[(5E)-5-(6-chloro-3-methyl-2(3H)-benzothiazolylidene)-3-ethyl-4-oxo-2-thiazolidinylidene]methyl]-3-(phenylmethyl)-,chloride (1:1)

参考文献

1. Li X. et al. ACS Med Chem Lett. 2013 Nov 14;4(11).

2. Li X, et al. Mol Cancer Ther. 2015 Mar;14(3):642-8.

JG-98 (JG98)

生物&药学活性

物理化学性质&存储条件

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JG-98 (JG98)

生物&药学活性

物理化学性质&存储条件

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