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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Heat Shock Protein (HSP)-JG-023
JG-023

Chemical Structure : JG-023

CAS No.: 2875070-03-2

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JG-023 (JG023)

货号: PC-23951Not For Human Use, Lab Use Only.

JG-023 is a novel isoform selective small-molecule inhibitor of HSPA5/6 with IC50 of <0.5 uM for both, shows selectivity for HSPA5 (BiP or GRP78) and HSPA6.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

JG-023 is a novel isoform selective small-molecule inhibitor of HSPA5/6 with IC50 of <0.5 uM for both, shows selectivity for HSPA5 (BiP or GRP78) and HSPA6.
JG-023 induced pro-apoptotic UPR signaling and enhanced the cytotoxic effects of proteasome inhibitors and other UPR-inducing drugs in CTCL but not normal T cells.
JG-023 also selectively suppressed the production of Th2 cytokines in CTCL and normal CD4+ T cells.

物理化学性质&存储条件

分子量 384.50
分子式 C20H24N4O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-((2S,3R)-1-((4,5-Dimethylthiazol-2-yl)amino)-3-methyl-1-oxopentan-2-yl)-1H-indole-2-carboxamide

参考文献

1. Nadia St Thomas, et al. Biomolecules. 2025 Jan 7;15(1):76.

2. Ambrose A.J., et al. J. Med. Chem. 2023;66:677–694.

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