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首页-小分子抑制剂&激动剂-GPCR-mGluR-JF-NP-26
JF-NP-26

Chemical Structure : JF-NP-26

CAS No.: 2341841-03-8

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JF-NP-26

货号: PC-27664Not For Human Use, Lab Use Only.

JF-NP-26 is a selecitve, photoactive mGlu5 receptor negative allosteric modulator (NAM), elicits with light pulses in the visible spectrum (405 nm), induces light-dependent analgesia in models of inflammatory and neuropathic pain in freely behaving animals.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

JF-NP-26 is a selecitve, photoactive mGlu5 receptor negative allosteric modulator (NAM), elicits with light pulses in the visible spectrum (405 nm), induces light-dependent analgesia in models of inflammatory and neuropathic pain in freely behaving animals.

物理化学性质&存储条件

分子量 513.57
分子式 C30H28FN3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(7-(diethylamino)-2-oxo-2H-chromen-4-yl)methyl (2-((3-fluorophenyl)ethynyl)-4,6-dimethylpyridin-3-yl)carbamate

参考文献

1. Font J, et al. Elife. 2017 Apr 11;6:e23545.

2. Mastroiacovo F, et al. Stroke. 2026 May;57(5):1349-1361.

3. López-Cano M, et al. Methods Mol Biol. 2019;1947:351-359.

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