JF-5 |CAS:481687-01-8 Probechem Biochemicals

Chemical Structure : JF-5

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JF-5 (PAR1 inhibitor JF5)

货号: PC-62040Not For Human Use, Lab Use Only.

JF5 (PAR1 inhibitor JF5) is an allosteric inhibitor of PAR1 that binds to helix 8 of the receptor.

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1 g		Get quote

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生物&药学活性

JF5 (PAR1 inhibitor JF5) is an allosteric inhibitor of PAR1 that binds to helix 8 of the receptor; inhibits PAR1 coupling to Gα subunits, but fails to inhibit signaling downstream of Gα12/13.
JF5 also interacts with the α2A-adrenergic receptor.
JF5 blocks granule secretion from platelets activated with the PAR1 agonist SFLLRN with IC50 of 4 uM, inhibits AYPGKF-mediated activation of murine platelets with IC50 of 10 uM.
JF5 inhibited thrombus formation in vivo following vascular injury with IC50 of 1 mg/kg.
JF5 is a useful probe to evaluate the role of H8 in coupling of GPCRs to cognate Gα subunits.

物理化学性质&存储条件

分子量	290.835
分子式	C17H22N2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,2,3,4-Tetrahydro-4-pentyl-9H-cyclopenta[b]quinolin-9-imine hydrochloride

参考文献

1. Dowal L, et al. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2951-6.

JF-5 (PAR1 inhibitor JF5)

生物&药学活性

物理化学性质&存储条件

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JF-5 (PAR1 inhibitor JF5)

生物&药学活性

物理化学性质&存储条件

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