JD-5006 | CB1 antagonist | Probechem Biochemicals

Chemical Structure : JD-5006

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JD-5006 (JD5006)

货号: PC-20518Not For Human Use, Lab Use Only.

JD-5006 is a potent, selective and peripherally restricted cannabinoid-1 (CB1) receptor blocker with IC50 of 18 nM, does not inhibit CB2 receptor (IC50>5000 nM).

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生物&药学活性

JD-5006 is a potent, selective and peripherally restricted cannabinoid-1 (CB1) receptor blocker with IC50 of 18 nM, does not inhibit CB2 receptor (IC50>5000 nM).
JD-5006 was also characterized as an inverse agonist in forskolin-stimulated CHO cells over- expressing CB1-receptors by its ability to affect cAMP with EC50 of 46 nM.
JD-5006 showed little brain presence as indicated by tissue distribution and receptor occupancy studies.
JD-5006 (20 mg/kg PO) normalized triglyceride levels, liver mass and ALT as well a beneficial effect on glycemic control in model of diabetes.

物理化学性质&存储条件

分子量	530.42
分子式	C24H21Cl2N5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(N)CN/C(N1N=C(C2=CC=C(Cl)C=C2)C(C3=CC=CC=C3)C1)=N\S(=O)(C4=CC=C(Cl)C=C4)=O

参考文献

1. Robert J Chorvat, et al. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6173-80.

JD-5006 (JD5006)

生物&药学活性

物理化学性质&存储条件

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JD-5006 (JD5006)

生物&药学活性

物理化学性质&存储条件

参考文献

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