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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-JCP276
JCP276

Chemical Structure : JCP276

CAS No.: 131068-67-2

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JCP276 (JCP 276)

货号: PC-72860Not For Human Use, Lab Use Only.

JCP276 is a novel antibiotic and covalent inhibitor that disrupt M. tuberculosis growth by targeting multiple serine hydrolases.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    JCP276 is a novel antibiotic and covalent inhibitor that disrupt M. tuberculosis growth by targeting multiple serine hydrolases.
    JCP276 is a narrow-spectrum inhibitor of Mycobacterium tuberculosis growth.
    JCP276 inhibits multiple nonessential serine hydrolases.
    JCP276 treatment caused accumulation of free lipids and a substantial decrease in lipooligosaccharides, linking SH inhibition to defects in cell envelope biogenesis.

    物理化学性质&存储条件

    分子量 451.70
    分子式 C19H16BrClN2O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(3-(3-bromopropoxy)-4-chloro-1-oxo-1H-isochromen-7-yl)-3-phenylurea

    参考文献

    1. Brett M Babin, et al. Cell Chem Biol. 2021 Sep 20;S2451-9456(21)00402-5.

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