JC19 | SARS-CoV-2 nsp14 degrader | Probechem Biochemicals

Chemical Structure : JC19

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JC19 (nsp14 degrader JC19)

货号: PC-21479Not For Human Use, Lab Use Only.

JC19 is a a cysteine-reactive small molecule degrader of SARS-CoV-2 nsp14 with DC50 of 8.7 uM in HEK293T cells.

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生物&药学活性

JC19 is a a cysteine-reactive small molecule degrader of SARS-CoV-2 nsp14 with DC50 of 8.7 uM in HEK293T cells.
JC19-induced nsp14 depletion is independent of canonical cell death pathways and electrophile sensing machinery.
JC19 effects degradation through direct modification of cysteines in both nsp14 and in host chaperones together with activation of global cell stress response pathways.

物理化学性质&存储条件

分子量	251.66
分子式	C8H7ClFNO3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2-chloroacetamido)benzenesulfonyl fluoride

参考文献

1. Ashley R Julio, et al. bioRxiv. 2023 Nov 16:2023.10.30.564067.

JC19 (nsp14 degrader JC19)

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物理化学性质&存储条件

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JC19 (nsp14 degrader JC19)

生物&药学活性

物理化学性质&存储条件

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