JBJ-04-125-02 | EGFR T790M/L858R inhibitor | Probechem Biochemicals

Chemical Structure : JBJ-04-125-02

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JBJ-04-125-02 (EGFR T790M/L858R inhibitor)

货号: PC-72984Not For Human Use, Lab Use Only.

JBJ-04-125-02 is a potent, mutant-selective, allosteric inhibitor of EGFR T790M/L858R with IC50 of 0.26 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

JBJ-04-125-02 is a potent, mutant-selective, allosteric inhibitor of EGFR T790M/L858R with IC50 of 0.26 nM.
JBJ-04-125-02 displays excellent selectivity against a panel of 468 kinases using the KINOMEscan approach (S-Score (35)=0.02).
JBJ-04-125-02 increases apoptosis and efficacy in vitro and in vivo compared with either single agent alone when combined with osimertinib.

物理化学性质&存储条件

分子量	543.617
分子式	C29H26FN5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2-yl)acetamid

参考文献

1. To C, et al. Cancer Discov. 2019 Jul;9(7):926-943.