JBI-097

Chemical Structure : JBI-097

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货号: PC-24003Not For Human Use, Lab Use Only.

JBI-097 is a potent, dual LSD1/HDAC6 inhibitor with IC50 of 6/48 nM respectively, also inhibits HDAC8 (IC50=71 nM), does not inhibit other HDACs.

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生物&药学活性

JBI-097 is a potent, dual LSD1/HDAC6 inhibitor with IC50 of 6/48 nM respectively, also inhibits HDAC8 (IC50=71 nM), does not inhibit other HDACs.
JBI-097 inhibited the proliferation of haematological cancers like acute myeloid leukaemia (AML), chronic myeloid leukaemia (CML), erythroleukaemia, and multiple myeloma with stronger potency with EC50 of 0.002-1.5 uM (MM1.S, EC50=2 nM).
JBI-097 also showed strong modulation of HDAC6 and LSD1 specific biomarkers, alpha-tubulin, CD86, CD11b, and GFi1b.
JBI-097 showed a stronger effect in erythroleukemia, multiple myeloma xenograft models, and in CT-26 syngeneic model.
JBI-097 also showed efficacy as monotherapy and additive or synergistic efficacy in combination with the standard of care or with immune checkpoint inhibitors.

物理化学性质&存储条件

分子量	407.56
分子式	C25H33N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-hydroxy-4-(3-(4-((((1S,2R)-2-phenylcyclopropyl)amino)methyl)piperidin-1-yl)propyl)benzamide

参考文献

1. Gajendran C, et al. PLoS One. 2023 Jan 3;18(1):e0279063.

JBI-097

生物&药学活性

物理化学性质&存储条件

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JBI-097

生物&药学活性

物理化学性质&存储条件

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