JAK3 inhibitor MJ04 | JAK3 inhibitor | Probechem Biochemicals

Chemical Structure : JAK3 inhibitor MJ04

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JAK3 inhibitor MJ04 (MJ04)

货号: PC-22203Not For Human Use, Lab Use Only.

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生物&药学活性

JAK3 inhibitor MJ04 is a potent and highly selective, ATP competitive JAK3 inhibitor with IC50 of 2.03 nM (2.5 µM ATP), >90-fold selectivity over JAK1 and JAK2, shows potential hair growth promoter activity.
MJ04 also displays high selectivity over a panel of other kinases which include IGF1R, GSK3β, EGFR, p110α, p110β, p110γ and p110δ.
MJ04 (0.37-6 uM) significantly decreases the phosphorylation status of STAT3 at Tyr705 in A549 cells.
MJ04 (0.08mg/kg, topically applied) promotes hair regrowth in the DHT induced AGA mice model.
MJ04 dampens the naive T-cell differentiation into proinflammatory phenotypes and inhibits the proinflammatory cytokines in LPS-induced macrophages.

物理化学性质&存储条件

分子量	345.38
分子式	C20H16FN5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-cyclopropyl-4-(5-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine

参考文献

1. Md Mehedi Hossain, et al. J Transl Med. 2024 Apr 18;22(1):370.

JAK3 inhibitor MJ04 (MJ04)

生物&药学活性

物理化学性质&存储条件

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JAK3 inhibitor MJ04 (MJ04)

生物&药学活性

物理化学性质&存储条件

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