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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-JAK-JAK3i
JAK3i

Chemical Structure : JAK3i

CAS No.: 1918238-72-8

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JAK3i (JAK3 inhibitor JAK3i)

货号: PC-62263Not For Human Use, Lab Use Only.

JAK3i is a potent, selective, covalent JAK3 kinase inhibitor with IC50 of 0.43 nM, shows high selectivity (>3,000-fold) against the closely related kinase domains in JAK1, JAK2, or TYK2.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

JAK3i is a potent, selective, covalent JAK3 kinase inhibitor with IC50 of 0.43 nM, shows high selectivity (>3,000-fold) against the closely related kinase domains in JAK1, JAK2, or TYK2.
JAK3i displays 1,300-fold, 600-fold, and 50-fold over EGFR, ITK, and BTK respectively.

物理化学性质&存储条件

分子量 354.34
分子式 C18H15FN4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Ethyl 4-(5-acrylamido-2-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate

参考文献

1. Smith GA, et al. Nat Chem Biol. 2016 May;12(5):373-9.

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