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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-JAK-JAK3-IN-1
JAK3-IN-1

Chemical Structure : JAK3-IN-1

CAS No.: 1805787-93-2

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JAK3-IN-1

货号: PC-45647Not For Human Use, Lab Use Only.

JAK3-IN-1 is a potent and selective JAK3 inhibitor with IC50 of 4.8 nM.

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5 mg ￥2380 In stock
10 mg ￥3880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

JAK3-IN-1 is a potent and selective JAK3 inhibitor with IC50 of 4.8 nM.
JAK3-IN-1 displays >150 fold selectivity versus JAK1 and JAK2.
JAK3-IN-1 exhibits decent pharmacokinetic properties and is suitable for use in vivo.

物理化学性质&存储条件

分子量 508.0151
分子式 C26H30ClN7O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 47 mg/mL
Chemical Name/SMILES

2-Propenamide, N-[3-[[[5-chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]methyl]phenyl]-

参考文献

1. Tan L, et al. J Med Chem. 2015 Aug 27;58(16):6589-606.

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