JAK-IN-35 |CAS:1400687-19-5 Probechem Biochemicals

Chemical Structure : JAK-IN-35

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JAK-IN-35 (JAK1/JAK3 inhibitor)

货号: PC-62841Not For Human Use, Lab Use Only.

JAK-IN-35 is a potent and efficacious dual JAK1/JAK3 inhibitor with IC50 of 0.9/1.9 nM.

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生物&药学活性

JAK-IN-35 is a potent and efficacious dual JAK1/JAK3 inhibitor with IC50 of 0.9/1.9 nM.
JAK-IN-35 shows weak activity against TYK2 and JAK2 (IC50=25 nM and15 nM respectively), also inhibits both ROCK1 (IC50=95 nM) and ROCK2 (IC50=43 nM).
JAK-IN-35 inhibits JAK1/3 mediated ex vivo processes in the mouse PD model (EC50 67 ± 13 nM).
JAK-IN-35 shows potential cardiovascular liabilities, specifically, QT interval prolongation.

物理化学性质&存储条件

分子量	408.506
分子式	C22H28N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(((1R,3S)-3-amino-2,2,3-trimethylcyclopentyl)amino)-6-(6-methoxypyridin-3-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide

参考文献

1. Hynes J Jr, et al. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3101-3106.

JAK-IN-35 (JAK1/JAK3 inhibitor)

生物&药学活性

物理化学性质&存储条件

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JAK-IN-35 (JAK1/JAK3 inhibitor)

生物&药学活性

物理化学性质&存储条件

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