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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-PARP-JA2131
JA2131

Chemical Structure : JA2131

CAS No.: 6505-99-3

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JA2131 (NSC98003)

货号: PC-73117Not For Human Use, Lab Use Only.

JA2131 (NSC98003) is a potent, selective small molecule PARG inhibitor with IC50 of 0.4 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    JA2131 (NSC98003) is a potent, selective small molecule PARG inhibitor with IC50 of 0.4 uM.
    JA2131 binds to the adenine-binding pocket of hPARG.
    JA2131 induces hyperPARylation of PARP1 in treated cells.
    JA2131 sensitizes cells to radiation-induced DNA damage, suppresses replication fork progression and impedes cancer cell survival.

    物理化学性质&存储条件

    分子量 341.448
    分子式 C13H19N5O2S2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2H-Purin-2-one,1,3,6,9-tetrahydro-1,3-dimethyl-8-[[2-(4-morpholinyl)ethyl]thio]-6-thioxo-

    参考文献

    1. Houl JH, et al. Nat Commun. 2019 Dec 11;10(1):5654.

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