J 147 |CAS:1146963-51-0 Probechem Biochemicals

Chemical Structure : J147

CAS No.: 1146963-51-0

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J147 (J 147)

货号: PC-61782Not For Human Use, Lab Use Only.

J 147 is a potent, orally active, memory enhancing and neurotrophic agent that protects against neurotoxicity in cortical neurons in vitro with EC50 of 25-200 nM.

规格	价格	库存
25 mg	￥1680	In stock
50 mg	￥2580	In stock
100 mg	￥3980	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

J147 is a potent, orally active, memory enhancing and neurotrophic agent that protects against neurotoxicity in cortical neurons in vitro with EC50 of 25-200 nM。
J147 reduces soluble Aβ40 and Aβ42 levels and increases BDNF levels in the hippocampus in vivo, reverses cognitive impairment in aged Alzheimer's disease mice。
J147 improves memory in aged AD mice, which is correlated with its induction of the neurotrophic factors NGF and BDNF as well as several BDNF-responsive proteins which are important for learning and memory.

物理化学性质&存储条件

分子量	350.33
分子式	C18H17F3N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,2,2-Trifluoroacetic acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide

参考文献

1. Prior M, et al. Alzheimers Res Ther. 2013 May 14;5(3):25.

2. Goldberg J, et al. Aging Cell. 2018 Jan 7. doi: 10.1111/acel.12715.

3. Kim K, et al. Org Biomol Chem. 2015 Oct 7;13(37):9564-9.

4. Chen HY, et al. J Mol Neurosci. 2015 Aug;56(4):977-987.

J147 (J 147)

生物&药学活性

物理化学性质&存储条件

参考文献

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J147 (J 147)

生物&药学活性

物理化学性质&存储条件

参考文献

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