J012-3168 | RPL11-MDM2 inhibitor | Probechem Biochemicals

Chemical Structure : J012-3168

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J012-3168 (RPL11-MDM2 inhibitor S9)

货号: PC-20010Not For Human Use, Lab Use Only.

RPL11-MDM2 inhibitor S9 (J012-3168) is a small-molecule RPL11 mimetic and potential inhibitor of RPL11-MDM2 interaction, directly binds MDM2 and induces p53 stabilization and activation.

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生物&药学活性

RPL11-MDM2 inhibitor S9 (J012-3168) is a small-molecule RPL11 mimetic and potential inhibitor of RPL11-MDM2 interaction, directly binds MDM2 and induces p53 stabilization and activation.
S9 stabilizes p53 and increases p53 transcriptional activity.
S9 inhibits cancer cell proliferation in vitro and in vivo, induces cell cycle arrest and apoptosis.

物理化学性质&存储条件

分子量	376.42
分子式	C21H20N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(6-oxo-1-(p-tolyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-4-yl)phenoxy)acetamide

参考文献

1. Bingwu Wang, et al. Mol Med. 2022 Sep 7;28(1):109.

J012-3168 (RPL11-MDM2 inhibitor S9)

生物&药学活性

物理化学性质&存储条件

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J012-3168 (RPL11-MDM2 inhibitor S9)

生物&药学活性

物理化学性质&存储条件

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