J-113863 | CCR1 inhibitor | Probechem Biochemicals

Chemical Structure : J-113863

CAS No.: 353791-85-2

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J-113863 (J113863)

货号: PC-20542Not For Human Use, Lab Use Only.

J-113863 is a potent, selective, non-peptide antagonist of CCR1 with IC50 of 0.9 and 5.8 nM for human and mouse CCR1 receptors, respectively.

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25 mg	￥2980	In stock
100 mg	￥7980	In stock
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生物&药学活性

J-113863 is a potent, selective, non-peptide antagonist of CCR1 with IC50 of 0.9 and 5.8 nM for human and mouse CCR1 receptors, respectively.
J-113863 is inactive against CCR2, CCR4 and CCR5, as well as the LTB4 or TNF-α receptors.
J-113863 is also a potent antagonist of the human CCR3 (IC50=0.58 nM), but a weak antagonist of the mouse CCR3 (IC50=460 nM).
J-113863 improved paw inflammation and joint damage, and dramatically decreased cell infiltration into joints.
J-113863 did not inhibit IL-2 or DTH, but reduced plasma TNFα levels in LPS-treated mice.
J-113863 prevents the progression of in collagen-induced arthritis (CIA) model.

物理化学性质&存储条件

分子量	655.44
分子式	C30H37Cl2IN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(1-cycloocten-1-ylmethyl)-4-(2,7-dichloroxanthen-9-ylcarboxamido)-1-ethylpiperidinium iodide

参考文献

1. Amat M, et al. Br J Pharmacol. 2006 Nov;149(6):666-75.

2. Price PJ, et al. J Virol. 2014 Sep;88(18):10840-50.

J-113863 (J113863)

生物&药学活性

物理化学性质&存储条件

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J-113863 (J113863)

生物&药学活性

物理化学性质&存储条件

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