J-113397 | NOP antagonist | Probechem Biochemicals

Chemical Structure : J-113397

CAS No.: 217461-40-0

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J-113397 ((±)-J 113397, J113397)

货号: PC-61545Not For Human Use, Lab Use Only.

J-113397 is a potent, selective nociceptin/orphanin FQ receptor (NOP receptor/ORL1) antagonist with IC50 of 2.3 nM.

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5 mg	￥2380	In stock
10 mg	￥3780	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

J-113397 is a potent, selective nociceptin/orphanin FQ receptor (NOP receptor/ORL1) antagonist with IC50 of 2.3 nM.
J-113397 displays >600-fold or less affinity for mu-, delta- and kappa-opioid receptors.
J-113397 inhibits nociceptin/orphanin FQ-induced suppression of cAMP accumulation elicited by forskolin with IC50 of 26 nM.
J-113397 dose-dependently inhibits hyperalgesia elicited by nociceptin/orphanin FQ in a tail-flick test with mice.

物理化学性质&存储条件

分子量	399.57
分子式	C24H37N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	rel-1-[(3R,4R)-1-(Cyclooctylmethyl)-3-(hydroxymethyl)-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one

参考文献

1. Kawamoto H, et al. J Med Chem. 1999 Dec 16;42(25):5061-3.

2. Ozaki S, et al. Eur J Pharmacol. 2000 Jan 17;387(3):R17-8.

3. Ozaki S, et al. Eur J Pharmacol. 2000 Aug 18;402(1-2):45-53.

J-113397 ((±)-J 113397, J113397)

生物&药学活性

物理化学性质&存储条件

参考文献

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J-113397 ((±)-J 113397, J113397)

生物&药学活性

物理化学性质&存储条件

参考文献

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