Ivosidenib (AG-120) | mutant IDH1 inhibitor | Probechem Biochemicals

Chemical Structure : Ivosidenib

CAS No.: 1448347-49-6

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Ivosidenib (AG-120, AG120)

货号: PC-45550Not For Human Use, Lab Use Only.

Ivosidenib (AG-120) is a potent, mutant-selective inhibitor of IDH1 (isocitrate dehydrogenase type 1) with IC50 of 12 nM for mouse IDH1 R132H.

规格	价格	库存
10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2480	In stock
100 mg	￥4280	In stock
250 mg		Get quote

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生物&药学活性

Ivosidenib (AG-120) is a potent, mutant-selective inhibitor of IDH1 (isocitrate dehydrogenase type 1) with IC50 of 12 nM for mouse IDH1 R132H.

Ivosidenib (AG-120) shows similar potency against IDH1-R132H (IC50=12 nM); IDH1-R132C (IC50=13 nM); IDH1-R132G (IC50=8 nM); IDH1-R132L (IC50=13 nM); IDH1-R132S (IC50=12 nM), respectively.

Ivosidenib (AG-120) (50 mg/kg and 150 mg/kg, orally gavage) suppresses tumor 2-HG concentration rapidly, with maximum inhibition (92.0% and 95.2% at the 50 mg/kg and 150 mg/kg doses, respectively).

Ivosidenib (AG-120) represent a worthwhile avenue of exploration in the treatment of IDH1-mutated tumors.

物理化学性质&存储条件

分子量	582.9609
分子式	C28H22ClF3N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 39 mg/mL
Chemical Name/SMILES	Glycinamide, 1-(4-cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)-, (2S)-

参考文献

1. Cuyàs E, et al. Oncotarget. 2015 May 20;6(14):12279-96.

2. Cancer Discov. 2015 Jan;5(1):4.

Ivosidenib (AG-120, AG120)

生物&药学活性

物理化学性质&存储条件

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Ivosidenib (AG-120, AG120)

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物理化学性质&存储条件

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