Israpafant (Y24180) | PAF antagonist | Probechem Biochemicals

Chemical Structure : Israpafant

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Israpafant (Y-24180, Y24180)

货号: PC-70046Not For Human Use, Lab Use Only.

Israpafant (Y24180) is a specific antagonist of PAF receptor that inhibits PAF-induced rabbit platelet aggregation in vitro (IC50=3.84 nM), with little effect on adenosine diphosphate- or arachidonic acid-induced aggregation.

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生物&药学活性

Israpafant (Y24180) is a specific antagonist of PAF receptor that inhibits PAF-induced rabbit platelet aggregation in vitro (IC50=3.84 nM), with little effect on adenosine diphosphate- or arachidonic acid-induced aggregation.
Israpafant antagonizes PAF-induced platelet aggregation dose-dependently in rabbits

物理化学性质&存储条件

分子量	489.074
分子式	C28H29ClN4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-chlorophenyl)-2-(4-isobutylphenethyl)-6,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine

参考文献

1. Takehara S, et al. Prostaglandins. 1990 Dec;40(6):571-83.

2. Kagoshima M, et al. Pharmacology. 1997 May;54(5):261-70.

3. Yamaguchi S, et al. Inflamm Res. 2000 Nov;49(11):584-90.

Israpafant (Y-24180, Y24180)

生物&药学活性

物理化学性质&存储条件

参考文献

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Israpafant (Y-24180, Y24180)

生物&药学活性

物理化学性质&存储条件

参考文献

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