Ispinesib |CAS:336113-53-2 Probechem Biochemicals

Chemical Structure : Ispinesib

CAS No.: 336113-53-2

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Ispinesib (SB-715992;SB 715992;SB715992)

货号: PC-45861Not For Human Use, Lab Use Only.

Ispinesib (SB-715992) is a potent, selective, cell-permeable, allosteric inhibitor of Eg5 (mitotic kinesin KSP) with Ki of 2.3 nM.

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10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

Ispinesib (SB-715992) is a potent, selective, cell-permeable, allosteric inhibitor of Eg5 (mitotic kinesin KSP) with Ki of 2.3 nM.
Ispinesib (SB-715992) displays >10,000-fold selectivity for Eg5 over a range of other mitotic kinesins.
Ispinesib (SB-715992) induces a monopolar spindle phenotype, leading to the activation of a spindle assembly checkpoint, mitotic arrest, and subsequent cell death with GI50 of 20-80 nM in colon, pancreas, prostrate, and lung cancer cells.
Ispinesib (SB-715992) demonstrates tumor regression of breast cancer cell xenografts in mice at 10 mg/kg.

物理化学性质&存储条件

分子量	517.0616
分子式	C30H33ClN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, N-(3-aminopropyl)-N-[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]-2-methylpropyl]-4-methyl-

参考文献

1. Good JA, et al. J Med Chem. 2013 Mar 14;56(5):1878-93.

2. Purcell JW, et al. Clin Cancer Res. 2010 Jan 15;16(2):566-76.

3. Luo L, et al. Nat Chem Biol. 2007 Nov;3(11):722-6. Epub 2007 Oct 7.

Ispinesib (SB-715992;SB 715992;SB715992)

生物&药学活性

物理化学性质&存储条件

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Ispinesib (SB-715992;SB 715992;SB715992)

生物&药学活性

物理化学性质&存储条件

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