Isothiafludine |CAS:960527-22-4 Probechem Biochemicals

Chemical Structure : Isothiafludine

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Isothiafludine (NZ-4)

货号: PC-63329Not For Human Use, Lab Use Only.

Isothiafludine (NZ-4) is a novel HBV capsid assembly inhibitor that inhibits HBV replication through blocking pregenomic RNA encapsidation, suppresses HBV replication in HepG2.2.15 cells with IC50 of 1.33 uM.

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生物&药学活性

Isothiafludine (NZ-4) is a novel HBV capsid assembly inhibitor that inhibits HBV replication through blocking pregenomic RNA encapsidation, suppresses HBV replication in HepG2.2.15 cells with IC50 of 1.33 uM.
Isothiafludine shows activity against the replication of various drug-resistant HBV mutants, including 3TC/ETV-dual-resistant and ADV-resistant HBV mutants.
Isothiafludine concentration-dependently reduces the encapsidated HBV pgRNA, resulting in the assembly of replication-deficient capsids in HepG2.2.15 cells.
Isothiafludine inhibits DHBV DNA replication in the DHBV-infected ducks after oral administration.

物理化学性质&存储条件

分子量	375.48
分子式	C18H18FN3OS2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(4-Fluorophenyl)methyl]-5-(2-methylpropyl)[2,2'-bithiazole]-4-carboxamide

参考文献

1. Yang L, et al. Acta Pharmacol Sin. 2014 Mar;35(3):410-8.

2. Yang L, et al. Antiviral Res. 2016 Jan;125:25-33.

Isothiafludine (NZ-4)

生物&药学活性

物理化学性质&存储条件

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Isothiafludine (NZ-4)

生物&药学活性

物理化学性质&存储条件

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