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首页-小分子抑制剂&激动剂-NF-κB Pathway-NF-κB-Isoliensinine
Isoliensinine

Chemical Structure : Isoliensinine

CAS No.: 6817-41-0

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Isoliensinine

货号: PC-27915Not For Human Use, Lab Use Only.

Isoliensinine is a bisbenzylisoquinoline alkaloid extracted from Nelumbo nucifera Gaertn., triggers HCC cell apoptosis via inducing p65 dephosphorylation at Ser536 and inhibition of NF-κB.

规格 价格 库存 数量
10 mg ￥780 In stock
25 mg ￥1280 In stock
50 mg ￥1980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Isoliensinine is a bisbenzylisoquinoline alkaloid extracted from Nelumbo nucifera Gaertn., triggers HCC cell apoptosis via inducing p65 dephosphorylation at Ser536 and inhibition of NF-κB.
Isoliensinine promotes p65/PP2A interaction in vitro and in vivo.
Isoliensinine directly impairs PP2A/I2PP2A interaction.
Isoliensinine induces apoptosis in triple-negative human breast cancer cells through ROS generation and p38 MAPK/JNK activation.
Isoliensinine ameliorates postoperative neurocognitive disorder in aged mice by restoring hippocampal IGF-1 receptor signaling and suppressing oxidative stress and neuroinflammation.

物理化学性质&存储条件

分子量 610.75
分子式 C37H42N2O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-1-(4-Hydroxy-3-(((R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy)benzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol

参考文献

1. Xiao JH, et al. Planta Med. 2005 Mar;71(3):225-30.

2. Shu G, et al. Oncotarget. 2016 Jun 28;7(26):40285-40296.

3. Zhang X, et al. Sci Rep. 2015 Jul 29;5:12579.

4. Zheng X, et al. Eur J Pharmacol. 2026 Feb 28;1016:178651.

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