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首页-小分子抑制剂&激动剂-Others-Other Targets-Isofagomine
Isofagomine

Chemical Structure : Isofagomine

CAS No.: 169105-89-9

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Isofagomine (Afegostat, D-Isofagomine)

货号: PC-27596Not For Human Use, Lab Use Only.

Isofagomine (Afegostat) is a broad spectrum inhibitor of glycosidases, inhibits beta-glucosidase, glucoamylase, isomaltase, and alpha-glucosidase, specifically and reversibly binds lysosomal hydrolase acid β-glucosidase (GCase) in the ER with high affinity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Isofagomine (Afegostat) is a broad spectrum inhibitor of glycosidases, inhibits beta-glucosidase, glucoamylase, isomaltase, and alpha-glucosidase, specifically and reversibly binds lysosomal hydrolase acid β-glucosidase (GCase) in the ER with high affinity.
Isofagomine (Afegostat) stabilizes the active form of GCase in the ER and increases trafficking of GCase to lysosomes.
Isofagomine (Afegostat) improved motor and nonmotor function, abolished microglial inflammatory response in the substantia nigra, reduced α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduced the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates.

物理化学性质&存储条件

分子量 147.17
分子式 C6H13NO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol

参考文献

1. Dong W, et al. Biochemistry. 1996 Feb 27;35(8):2788-95.

2. Waagepetersen HS, et al. Neurochem Int. 2000 Apr;36(4-5):435-40.

3. Richter F, et al. Neurotherapeutics. 2014 Oct;11(4):840-56.

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