Isobavachalcone | Akt inhibitor | Probechem Biochemicals

Chemical Structure : Isobavachalcone

CAS No.: 20784-50-3

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Isobavachalcone (Corylifolinin, Isobacachalcone)

货号: PC-43370Not For Human Use, Lab Use Only.

Isobavachalcone (Corylifolinin, Isobacachalcone) is a chalcone constituent of Angelica keiskei that can induce apoptosis in several cancer cells, is a potent inhibitor of Akt signaling pathway.

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10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

Isobavachalcone (Corylifolinin, Isobacachalcone) is a chalcone constituent of Angelica keiskei that can induce apoptosis in several cancer cells, is a potent inhibitor of Akt signaling pathway.
Isobavachalcone also shows activity against multidrug-resistant (MDR) Gram-negative bacterial isolates.
Isobavachalcone significantly reduces pro-caspase-3 and pro-caspase-9, and subsequently increases the level of cleaved caspase-3 and cleaved caspase-9 in neuroblastoma cell lines also exhibiting deletions of the major efflux pump components (AcrAB, TolC).

物理化学性质&存储条件

分子量	324.3704
分子式	C20H20O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 11 mg/mL
Chemical Name/SMILES	2-Propen-1-one, 1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-, (2E)-

参考文献

1. Nishimura R, et al. Biol Pharm Bull. 2007 Oct;30(10):1878-83.

2. Kuete V, et al. Antimicrob Agents Chemother. 2010 May;54(5):1749-52.

3. Jing H, et al. Cancer Lett. 2010 Aug 28;294(2):167-77.

Isobavachalcone (Corylifolinin, Isobacachalcone)

生物&药学活性

物理化学性质&存储条件

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Isobavachalcone (Corylifolinin, Isobacachalcone)

生物&药学活性

物理化学性质&存储条件

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