Isoalantolactone | Apoptosis inducer | Probechem Biochemicals

Chemical Structure : Isoalantolactone

CAS No.: 470-17-7

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Isoalantolactone ((+)-Isoalantolactone, Isohelenin)

货号: PC-27107Not For Human Use, Lab Use Only.

Isoalantolactone is a sesquiterpene lactone compound isolated from the roots of Inula helenium L., induces apoptosis in various cancer cell lines.

规格	价格	库存
25 mg	￥580	In stock
100 mg	￥980	In stock
250 mg		Get quote
1 g		Get quote

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生物&药学活性

Isoalantolactone is a sesquiterpene lactone compound isolated from the roots of Inula helenium L., induces apoptosis in various cancer cell lines.
Isoalantolactone induces apoptosis in SGC-7901 cells via mitochondrial and phosphatidylinositol 3-kinase/Akt signaling pathways.
Isoalantolactone induces reactive oxygen species (ROS) mediated apoptosis in pancreatic carcinoma PANC-1 cells.
Isoalantolactone induces intrinsic apoptosis through p53 signaling pathway in human lung squamous carcinoma cells.
Isoalantolactone inhibits LPS-induced inflammation via NF-kappaB inactivation in peritoneal macrophages and improves survival in sepsis.
Isoalantolactone induces apoptosis through ROS-mediated ER stress and inhibition of STAT3 in prostate cancer cells.

物理化学性质&存储条件

分子量	232.32
分子式	C15H20O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3aR,4aS,8aR,9aR)-8a-Methyl-3,5-dimethylenedecahydronaphtho[2,3-b]furan-2(3H)-one

参考文献

1. Stampf JL, et al. Br J Dermatol. 1978 Aug;99(2):163-9.

2. Lawrence NJ, et al. Bioorg Med Chem Lett. 2001 Feb 12;11(3):429-31.

3. Di W, et al. Oncol Rep. 2014 Oct;32(4):1585-93.

Isoalantolactone ((+)-Isoalantolactone, Isohelenin)

生物&药学活性

物理化学性质&存储条件

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Isoalantolactone ((+)-Isoalantolactone, Isohelenin)

生物&药学活性

物理化学性质&存储条件

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