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Ischemin

Chemical Structure : Ischemin

CAS No.: 1357059-00-7

Ischemin (CBP bromodomain inhibitor)

货号: PC-60199Not For Human Use, Lab Use Only.

Ischemin is a cell permeable CBP bromodomain inhibitor with Kd of 19 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Ischemin is a cell permeable CBP bromodomain inhibitor with Kd of 19 uM.
    Ischemin inhibits the acetyl-lysine binding activity of CBP, inhibits p53 interaction with CBP and decreases p53 transcriptional activity.
    Ischemin protects against doxorubicin-induced apoptosis in cardiomyocytes in vitro.

    物理化学性质&存储条件

    分子量 335.378
    分子式 C15H17N3O4S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    5-[(1E)-2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-2,4-dimethylbenzenesulfonic acid

    参考文献

    1. Borah JC, et al. Chem Biol. 2011 Apr 22;18(4):531-41.

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