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首页-抗体和重组蛋白-Biosimilar Antibody-Isatuximab
Isatuximab

Chemical Structure : Isatuximab

CAS No.: 1461640-62-9

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Isatuximab (Anti-human CD38 mAb, human IgG1-Kappa; SAR650984)

货号: PC-Ab1044Not For Human Use, Lab Use Only.

Isatuximab (SAR650984) binds to a CD38 epitope distinct from that targeted by daratumumab, and can be further differentiated from the latter on the basis of several mechanistic differences, including the ability to induce apoptosis of CD38-expressing cells directly. Isatuximab induces antibody-dependent cell-mediated cytotoxicity, antibody-dependent cellular phagocytosis, and complement dependent cytotoxicity..

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1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Isatuximab (SAR650984) binds to a CD38 epitope distinct from that targeted by daratumumab, and can be further differentiated from the latter on the basis of several mechanistic differences, including the ability to induce apoptosis of CD38-expressing cells directly. Isatuximab induces antibody-dependent cell-mediated cytotoxicity, antibody-dependent cellular phagocytosis, and complement dependent cytotoxicity.

物理化学性质&存储条件

分子量
分子式 Human IgG1-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Isatuximab; Sarclisa; isatuximab-irfc; SAR650984; SAR 650984; anti-CD38; CD38 Antigen; Cluster Of Differentiation 38

参考文献

1. 1, Attal M, et al. Lancet. 2019 Dec 7;394(10214):2096-2107. 2, Martin TG, et al. Cells. 2019 Nov 26;8(12):1522. 3, Moreno L, et al. Clin Cancer Res. 2019 May 15;25(10):3176-3187.  4, Zhu C, et al. Front Immunol. 2020 Aug 14;11:1771.  5, Feng X, et al. Clin Cancer Res. 2017 Aug 1;23(15):4290-4300.

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