Chemical Structure : Isatuximab
CAS No.: 1461640-62-9
货号: PC-Ab1044Not For Human Use, Lab Use Only.
Isatuximab (SAR650984) binds to a CD38 epitope distinct from that targeted by daratumumab, and can be further differentiated from the latter on the basis of several mechanistic differences, including the ability to induce apoptosis of CD38-expressing cells directly. Isatuximab induces antibody-dependent cell-mediated cytotoxicity, antibody-dependent cellular phagocytosis, and complement dependent cytotoxicity..
规格 | 价格 | 库存 | 数量 |
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1 mg | ¥3580 | In stock | |
5 mg | ¥7580 | In stock | |
10 mg | ¥12800 | In stock | |
100 mg | Get quote |
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Isatuximab (SAR650984) binds to a CD38 epitope distinct from that targeted by daratumumab, and can be further differentiated from the latter on the basis of several mechanistic differences, including the ability to induce apoptosis of CD38-expressing cells directly. Isatuximab induces antibody-dependent cell-mediated cytotoxicity, antibody-dependent cellular phagocytosis, and complement dependent cytotoxicity.
分子量 | ||
分子式 | Human IgG1-Kappa | |
外观性状 | Solid | |
储存条件 |
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Solubility |
PBS, pH 7.0 Contains no stabilizers or preservatives |
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Chemical Name/SMILES |
Isatuximab; Sarclisa; isatuximab-irfc; SAR650984; SAR 650984; anti-CD38; CD38 Antigen; Cluster Of Differentiation 38 |
1. 1, Attal M, et al. Lancet. 2019 Dec 7;394(10214):2096-2107. 2, Martin TG, et al. Cells. 2019 Nov 26;8(12):1522. 3, Moreno L, et al. Clin Cancer Res. 2019 May 15;25(10):3176-3187. 4, Zhu C, et al. Front Immunol. 2020 Aug 14;11:1771. 5, Feng X, et al. Clin Cancer Res. 2017 Aug 1;23(15):4290-4300.
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