Isatoribine |CAS:122970-40-5 Probechem Biochemicals

Chemical Structure : Isatoribine

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Isatoribine (ANA245;7-Thia-8-oxoguanosine;Immunosine)

货号: PC-62779Not For Human Use, Lab Use Only.

Isatoribine (ANA245; 7-Thia-8-oxoguanosine; Immunosine) is a nucleoside analogue, selective agonist of TLR7 with significant antiviral effect and mmunoenhancing activity.

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生物&药学活性

Isatoribine (ANA245; 7-Thia-8-oxoguanosine; Immunosine) is a nucleoside analogue, selective agonist of TLR7 with significant antiviral effect and mmunoenhancing activity.
Isatoribine (ANA245) stimulates proliferation of thymocytes in vitro, stimulates IL-2 production and the expression of activation markers (CD25 and CD71).
Isatoribine (ANA245) reduces plasma virus concentration in chronic HCV infection。
Isatoribine (ANA245) also increase the efficacy of a weakly immunogenic murine L1210 leukemia vaccine in vivo.

物理化学性质&存储条件

分子量	316.288
分子式	C10H12N4O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-amino-3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4H-[1,3]thiazolo[4,5-d]pyrimidine-2,7-dione

参考文献

1. Horsmans Y, et al. Hepatology. 2005 Sep;42(3):724-31.

2. Smee DF, et al. Antiviral Res. 1991 Mar-Apr;15(3):229-39.

3. Jin A, et al. Cell Immunol. 1990 Apr 1;126(2):414-9.

4. Sharma BS, et al. Cancer Immunol Immunother. 1991;33(2):109-14.

Isatoribine (ANA245;7-Thia-8-oxoguanosine;Immunosine)

生物&药学活性

物理化学性质&存储条件

参考文献

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Isatoribine (ANA245;7-Thia-8-oxoguanosine;Immunosine)

生物&药学活性

物理化学性质&存储条件

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