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Irresistin-16

Chemical Structure : Irresistin-16

CAS No.: 2624247-60-3

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Irresistin-16 (IRS-16)

货号: PC-22131Not For Human Use, Lab Use Only.

Irresistin-16 (IRS-16) is a potent bacterial dihydrofolate reductase (DHFR) inhibitor for purified E. coli DHFR (FolA), exhibits potent activity against S.aureus MRSA and N. gonorrhoeae with MIC of 1.56 and 0.03 ug/mL, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Irresistin-16 (IRS-16) is a potent bacterial dihydrofolate reductase (DHFR) inhibitor for purified E. coli DHFR (FolA), exhibits potent activity against S.aureus MRSA and N. gonorrhoeae with MIC of 1.56 and 0.03 ug/mL, respectively.
Irresistin-16 (IRS-16) (10 mg/kg, i.v., twice a day [b.i.d.]) reduces the vaginal burden of N. gonorrhoeae 24 h after inoculation in mice.

物理化学性质&存储条件

分子量 365.44
分子式 C23H19N5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

7-([1,1'-biphenyl]-4-ylmethyl)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine

参考文献

1. Martin JK 2nd, et al. Cell. 2020 Jun 25;181(7):1518-1532.e14.

2. Hu X, et al. Pathogens. 2022 Jan 6;11(1):70.

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