Ironomycin | Ferroptosis inducer | Probechem Biochemicals

Chemical Structure : Ironomycin

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Ironomycin (Ironomycin AM5)

货号: PC-72335Not For Human Use, Lab Use Only.

Ironomycin (Ironomycin AM5) is a lysosomal iron-targeting small molecule that reduces the mitochondrial iron load, resulting in the potent disruption of mitochondrial metabolism.

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生物&药学活性

Ironomycin (Ironomycin AM5) is a lysosomal iron-targeting small molecule that reduces the mitochondrial iron load, resulting in the potent disruption of mitochondrial metabolism, induces ferroptosis in cancer cells.
Ironomycin promotes the recruitment and activation of BAX/BAK, but the resulting mitochondrial outer membrane permeabilization (MOMP) does not lead to potent activation of the apoptotic caspases, nor is the ensuing cell death prevented by inhibiting the previously established pathways of programmed cell death.
Ironomycin exhibits marked in vitro and in vivo synergy with venetoclax and overcomes venetoclax resistance in primary patient samples.
Ironomycin AM5 exhibits a more potent and selective activity against breast cancer stem cells (CSCs) in vitro and in vivo, by accumulating and sequestering iron in lysosomes.

物理化学性质&存储条件

分子量	709
分子式	C45H73NO10
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility
Chemical Name/SMILES	(2R)-2-[(2R,5S,6R)-6-{(2S,3S,4S,6R)-6-[(2S,5S,7R,9S,10S,12R,15R)-2-[(2R,5R,6S)-5-Ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]-2,10,12-trimethyl-15-(2-propyn-1-ylamino)-1,6,8-trioxadispiro[4.1.5.3 ]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxo-2-octanyl}-5-methyltetrahydro-2H-pyran-2-yl]butanoic acid

参考文献

1. Garciaz S, et al. Cancer Discov. 2021 Dec 3. doi: 10.1158/2159-8290.CD-21-0522.

2. Devin J, et al. Cancer Res. 2022 Jan 25:canres.0218.2021.

3. Versini A, et al. Chemistry. 2020 Jun 10;26(33):7416-7424.

4. Mai TT, et al. Nat Chem. 2017 Oct;9(10):1025-1033.

Ironomycin (Ironomycin AM5)

生物&药学活性

物理化学性质&存储条件

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Ironomycin (Ironomycin AM5)

生物&药学活性

物理化学性质&存储条件

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