Irbesartan | AT1 receptor antagonist | Probechem Biochemicals

Chemical Structure : Irbesartan

CAS No.: 138402-11-6

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Irbesartan (SR 47436, BMS-186295)

货号: PC-23855Not For Human Use, Lab Use Only.

规格	价格	库存
10 mg	￥480	In stock
50 mg	￥780	In stock
100 mg	￥1180	In stock
250 mg	￥1980	In stock
1 g		Get quote

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生物&药学活性

Irbesartan (SR 47436) is a potent, selective nonpeptide AT1 angiotensin II receptor (AT1 receptor) antagonist, inhibits [125I]AII binding to AT1 subtype receptors in rat liver membrane with IC50 of 1.7 nM, with no effect on AT2 subtypes.
Irbesartan (SR 47436) inhibits contractions induced by 10 nM AII (IC50 = 4.0 nM) in rabbit aorta.
Irbesartan (SR 47436) is lack of activity (IC50 > 10 microM) on various other receptors, ionic channels and antiports and rabbit aorta contracted by norepinephrine and KCl, and lack of inhibition of renin and converting enzyme.
Irbesartan (SR 47436) antagonized the AII-pressor response in a dose-related manner in conscious rats.

物理化学性质&存储条件

分子量	428.54
分子式	C25H28N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one

参考文献

1. Lacour C, et al. J Hypertens. 1993 Nov;11(11):1187-94.

2. Cazaubon C, et al. J Pharmacol Exp Ther. 1993 May;265(2):826-34.

Irbesartan (SR 47436, BMS-186295)

生物&药学活性

物理化学性质&存储条件

参考文献

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Irbesartan (SR 47436, BMS-186295)

生物&药学活性

物理化学性质&存储条件

参考文献

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