Irampanel | AMPAR antagonist | Probechem Biochemicals

Chemical Structure : Irampanel

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Irampanel (BIIR561)

货号: PC-61709Not For Human Use, Lab Use Only.

Irampanel (BIIR 561) is a combined antagonist of AMPA receptors (AMPAR) and voltage-dependent sodium channels.

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生物&药学活性

Irampanel (BIIR 561) is a combined antagonist of AMPA receptors (AMPAR) and voltage-dependent sodium channels.
Irampanel (BIIR 561) noncompetitively inhibits AMPA receptor-mediated membrane currents in cultured cortical neurons with IC50 of 8.5 uM, reduces sodium currents in voltage-clamped cortical neurons with IC50 of 5.2 uM and inhibits the veratridine-induced release of glutamate from rat brain slices with IC50 of 2.3 uM.
Irampanel (BIIR 561) shows anticonvulsive and neuroprotective properties in mice.

物理化学性质&存储条件

分子量	309.362
分子式	C18H19N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N,N-Dimethyl-N-[2-[2-(3-phenyl-1,2,4-oxadiazol-5-yl)phenoxy]ethyl]amine

参考文献

1. Weiser T, et al. J Pharmacol Exp Ther. 1999 Jun;289(3):1343-9.

2. Weiser T, et al. Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;362(4-5):419-26.

3. Wienrich M, et al. Br J Pharmacol. 2001 Jul;133(6):789-96.

Irampanel (BIIR561)

生物&药学活性

物理化学性质&存储条件

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Irampanel (BIIR561)

生物&药学活性

物理化学性质&存储条件

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