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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-SGLT-Ipragliflozin
Ipragliflozin

Chemical Structure : Ipragliflozin

CAS No.: 761423-87-4

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Ipragliflozin (ASP1941, ASP-1941)

货号: PC-44115Not For Human Use, Lab Use Only.

Ipragliflozin (ASP1941) is a highly potent and selective SGLT2 inhibitor with IC50 of 14 nM for hSGLT2.

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10 mg ￥980 In stock
25 mg ￥1480 In stock
50 mg ￥2380 In stock
100 mg ￥3780 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Ipragliflozin (ASP1941) is a highly potent and selective SGLT2 inhibitor with IC50 of 14 nM for hSGLT2.
Ipragliflozin shows 254-fold selectivity over hSGLT1.
Ipragliflozin reduces blood glucose levels in a dose-dependent manner in diabetic models KK-A(y) mice and STZ rats.

物理化学性质&存储条件

分子量 404.4518
分子式 C21H21FO5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

D-Glucitol, 1,5-anhydro-1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-, (1S)-

参考文献

1. Imamura M, et al. Bioorg Med Chem. 2012 May 15;20(10):3263-79.

2. Tahara A, et al. J Pharmacol Sci. 2012;120(1):36-44.

3. Tahara A, et al. Eur J Pharmacol. 2013 Sep 5;715(1-3):246-55.

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