Ipatasertib (GDC-0068, RG7440)

Chemical Structure : Ipatasertib

CAS No.: 1001264-89-6

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货号: PC-49017Not For Human Use, Lab Use Only.

Ipatasertib (GDC-0068) is a potent, selective, orally bioavailable pan-Akt inhibitor with IC50 values of 5 nM, 18 nM, and 8 nM for Akt1, Akt2, and Akt3, respectively.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2680	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

Ipatasertib (GDC-0068, RG7440) is a potent, selective, orally bioavailable pan-Akt inhibitor with IC50 values of 5 nM, 18 nM, and 8 nM for Akt1, Akt2, and Akt3, respectively.
GDC-0068 blocked Akt signaling both in cultured human cancer cell lines and in tumor xenograft models as evidenced by dose-dependent decrease in phosphorylation of downstream targets.
GDC-0068 blocks cell-cycle progression and reduced viability of cancer cell lines.
Oral administration of GDC-0068 resulted in antitumor activity ranging from tumor growth delay to regression in multiple tumor xenograft models.

物理化学性质&存储条件

分子量	458.003
分子式	C24H32ClN5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S)-(4-chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone

参考文献

1. Blake JF, et al. J Med Chem. 2012 Sep 27;55(18):8110-27.

2. Lin J, et al. Clin Cancer Res. 2013 Apr 1;19(7):1760-72.

3. Zhai B, et al. Mol Cancer Ther. 2014 Jun;13(6):1589-98.