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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Liver X Receptor (LXR)-Inotodiol
Inotodiol

Chemical Structure : Inotodiol

CAS No.: 35963-37-2

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Inotodiol (CE9A215)

货号: PC-23926Not For Human Use, Lab Use Only.

Inotodiol (CE9A215) is a lanostane-type triterpenoid compound isolated from the sclerotia of Inonotus obliquus, a selective LXRβ agonist with EC50 of <10 nM, shows potent anti-allergic and anti-inflammatory effects.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Inotodiol (CE9A215) is a lanostane-type triterpenoid compound isolated from the sclerotia of Inonotus obliquus, a selective LXRβ agonist with EC50 of <10 nM, shows potent anti-allergic and anti-inflammatory effects.
Inotodiol (CE9A215) shows no significant activation observed for LXRα at concentrations up to 1000 nM.
Inotodiol (CE9A215) crosses the blood-brain barrier and accumulates in the brain.
Inotodiol (CE9A215) modulated the expression of ABCA1, APOE, SREBP-1c and AQP4 in the brains of wild-type and LXR α/β knockout mice in LXRβ-dependent manner.
Inotodiol (CE9A215) exerted both prophylactic and therapeutic effects on AD-associated behaviors and pathologies, including reductions in amyloid-β, phosphorylated tau, and neuroinflammation in the hippocampus in AD-related pathologies of 3xTg-AD mice.

物理化学性质&存储条件

分子量 442.73
分子式 C30H50O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Lanosta-8,24-diene-3,22-diol, (3β,22R)-

参考文献

1. Ban SY, et al. Biomed Pharmacother. 2025 Feb 6;184:117895.

2. Nakata T, et al. Bioorg Med Chem. 2007;15(1):257-264.

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