InhiTinib

Chemical Structure : InhiTinib

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货号: PC-38144Not For Human Use, Lab Use Only.

InhiTinib is a small molecule that inhibit interferon (IFN)-gamma production (IC50=52.44 nM) and proliferation of primary CD3+ T cells without inducing cell death.

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生物&药学活性

InhiTinib is a small molecule that inhibit interferon (IFN)-gamma production (IC50=52.44 nM) and proliferation of primary CD3+ T cells without inducing cell death。
InhiTinib blocks IFN-gamma production from T cells co-cultured with allogeneic BMDCs in a one-way mixed lymphocyte reaction (MLR) and inhibits T-cell proliferation in a CellTrace dilution assay without inducing apoptosis.
InhiTinib decreases IFN-gamma production from activated CB-derived human CD3+ T cells (IC50=1.5 uM).
InhiTinib triggered apoptosis in several murine and human cancer cell lines.
InhiTinib was well tolerated by immunocompetent mice, triggered tumor regression in animals with pre-established EL4 T-cell lymphomas, and prolonged the overall survival of mice harboring advanced tumors.

物理化学性质&存储条件

分子量	369.82
分子式	C15H16ClN3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-chloro-N-(2-ethoxyphenyl)-2-(ethylsulfonyl)-4-pyrimidinecarboxamide

参考文献

1. Abed El-Hakim El-Kadiry, et al. Front Pharmacol. 2020 Mar 12;11:237.

InhiTinib

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InhiTinib

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