Indostat

Chemical Structure : Indostat

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货号: PC-28756Not For Human Use, Lab Use Only.

Indostat is a potent, selective HDAC6 inhibitor with IC50 of 14.7 nM (hHDAC6), exhibiting negligible activity against hHDAC1, hHDAC8, and hHDAC10.

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生物&药学活性

Indostat is a potent, selective HDAC6 inhibitor with IC50 of 14.7 nM (hHDAC6), exhibiting negligible activity against hHDAC1, hHDAC8, and hHDAC10.
Indostat (1-50 uM) increases α-tubulin acetylation over histone H3 acetylation in SH-SY5Y cells.
Indostat (0.1-20 uM) markedly attenuates poly I:C–induced inflammation quantified by measuring IL-6 secretion in hippocampal neuronal cells.
Indostat shows anti-inflammatory efficacy comparable to the pan-HDAC inhibitor SAHA, but with improved cellular tolerability.

物理化学性质&存储条件

分子量	422.44
分子式	C22H22N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(Hydroxycarbamoyl)benzyl)-1-(morpholine-4-carbonyl)indolizine-3-carboxamide

参考文献

1. Fontana A, et al. Eur J Med Chem. 2026 Nov 7;321(Pt 3):119496.

Indostat

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物理化学性质&存储条件

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Indostat

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