Indirubin E804 |CAS:854171-35-0 Probechem Biochemicals

Chemical Structure : Indirubin E804

CAS No.: 854171-35-0

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Indirubin E804 (E804)

货号: PC-61235Not For Human Use, Lab Use Only.

Indirubin E804 is an indirubin derivative that potently blocks constitutive STAT3 signaling in human breast and prostate cancer cells, directly inhibits Src kinase activity (IC50=0.43 uM) in vitro.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥3980	In stock
100 mg		Get quote

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生物&药学活性

Indirubin E804 is an indirubin derivative that potently blocks constitutive STAT3 signaling in human breast and prostate cancer cells, directly inhibits Src kinase activity (IC50=0.43 uM) in vitro.
E804 decreases tyrosyl phosphorylation of Stat3, suppresses constitutive Stat3 DNA binding-activity in treated cells, also down-regulates antiapoptotic proteins Mcl-1 and Survivin.
E804 inhibits the subintestinal vessels formation in zebrafish embryos.

物理化学性质&存储条件

分子量	365.389
分子式	C20H19N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[3-[(3,4-Dihydroxybutoxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one

参考文献

1. Nam S, et al. Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):5998-6003.

2. Zhou J, et al. Blood. 2009 Apr 23;113(17):4052-62.

3. Chan YK, et al. Biochem Pharmacol. 2012 Mar 1;83(5):598-607.

4. Nam S, et al. Mol Oncol. 2012 Jun;6(3):276-83.

Indirubin E804 (E804)

生物&药学活性

物理化学性质&存储条件

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Indirubin E804 (E804)

生物&药学活性

物理化学性质&存储条件

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