Indirubin-3'-monoxime | GSK3β inhibitor | Probechem Biochemicals

Chemical Structure : Indirubin-3-monoxime

CAS No.: 160807-49-8

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Indirubin-3-monoxime (Indirubin-3'-monoxime)

货号: PC-45724Not For Human Use, Lab Use Only.

Indirubin-3'-monoxime is a potent GSK3β inhibitor with IC50 of 22 nM, prevents tau phosphorylation both in vitro and in vivo.

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10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥2180	In stock
100 mg		Get quote

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生物&药学活性

Indirubin-3'-monoxime is a potent GSK3β inhibitor with IC50 of 22 nM, prevents tau phosphorylation both in vitro and in vivo.
Indirubin-3'-monoxime also inhibits CDKs at higher concentrations, including Cdk1/cyclin B (IC50=180 nM), Cdk2/cyclin A (IC50~500 nM), Cdk2/cyclin E (IC50=250nM), Cdk4/cyclin D1 (IC50=3.3 uM) and Cdk5/p35 (IC50=100 nM).
Indirubin-3'-monoxime reversibly inhibits the proliferation of many cells types, arresting cycling in the G2/M phase.

物理化学性质&存储条件

分子量	277.2774
分子式	C16H11N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 37 mg/mL
Chemical Name/SMILES	2H-Indol-2-one, 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-

参考文献

1. Leclerc S, et al. J Biol Chem. 2001 Jan 5;276(1):251-60.

2. Hoessel R, et al. Nat Cell Biol. 1999 May;1(1):60-7.

3. Damiens E, et al. Oncogene. 2001 Jun 28;20(29):3786-97.

Indirubin-3-monoxime (Indirubin-3'-monoxime)

生物&药学活性

物理化学性质&存储条件

参考文献

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Indirubin-3-monoxime (Indirubin-3'-monoxime)

生物&药学活性

物理化学性质&存储条件

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