Inaxaplin (VX-147) | APOL1 inhibitor | Probechem Biochemicals

Chemical Structure : Inaxaplin

CAS No.: 2446816-88-0

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Inaxaplin (VX-147, VX147)

货号: PC-38400Not For Human Use, Lab Use Only.

Inaxaplin (VX-147, VX147) is a potent small molecule inhibitor of apolipoprotein L1 (APOL1) channel with IC50 values of 2.3 nM for APOL1 G0, 1.3 nM for APOL1 G1, and 1.1 nM for APOL1 G2, inhibits APOL1-mediated flux and cell death.

规格	价格	库存
2 mg	￥1980	In stock
5 mg	￥3280	In stock
10 mg	￥5280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Inaxaplin (VX-147, VX147) is a potent small molecule inhibitor of apolipoprotein L1 (APOL1) channel with IC50 values of 2.3 nM for APOL1 G0, 1.3 nM for APOL1 G1, and 1.1 nM for APOL1 G2, inhibits APOL1-mediated flux and cell death.

VX-147 prevented APOL1-mediated T.b.b. death with essentially equivalent potencies to ion channel inhibition, with EC50 values of 2.0 nM for APOL1 G0, 2.1 nM for APOL1 G1, and 1.2 nM for APOL1 G2.

VX-147 inhibits APOL1-dependent cell death with EC50 values of 4.3 nM for APOL1 G0, 2.0 nM for APOL1 G1, and 2.2 nM for APOL1 G2.

VX-147 inhibits APOL1-mediated cell death and kidney damage in a transgenic mouse model.

物理化学性质&存储条件

分子量	417.388
分子式	C21H18F3N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(5,7-difluoro-2-(4-fluorophenyl)-1H-indol-3-yl)-N-((3S,4R)-4-hydroxy-2-oxopyrrolidin-3-yl)propanamide

参考文献

1. Patent US20210275496 A1.
2. Egbuna O, et al. N Engl J Med. 2023 Mar 16;388(11):969-979.
3. Zimmerman B, et al. Nat Commun. 2025 Jan 2;16(1):167.

Inaxaplin (VX-147, VX147)

生物&药学活性

物理化学性质&存储条件

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Inaxaplin (VX-147, VX147)

生物&药学活性

物理化学性质&存储条件

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