InS3-54 |CAS:328998-92-1 Probechem Biochemicals

Chemical Structure : InS3-54

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InS3-54 (STAT3 inhibitor)

货号: PC-62378Not For Human Use, Lab Use Only.

InS3-54 is a small molecule STAT3 inhibitor that selectively targets the DNA-binding domain of STAT3, without affecting the activation and dimerization of STAT3.

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生物&药学活性

InS3-54 is a small molecule STAT3 inhibitor that selectively targets the DNA-binding domain of STAT3, without affecting the activation and dimerization of STAT3.
InS3-54 preferentially suppresses proliferation of cancer over non-cancer cells and inhibits migration and invasion of malignant cells.
InS3-54 selectively inhibits STAT3 binding to DNA without affecting the activation and dimerization of STAT3.
InS3-54 inhibits expression of STAT3 downstream target genes and STAT3 binding to chromatin in situ.

物理化学性质&存储条件

分子量	412.401
分子式	C24H16N2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-4-(3-(4-nitrobenzylidene)-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl)benzoic acid

参考文献

1. Huang W, et al. ACS Chem Biol. 2014 May 16;9(5):1188-96.

2. Huang W, et al. Oncogene. 2016 Feb 11;35(6):783-92.

InS3-54 (STAT3 inhibitor)

生物&药学活性

物理化学性质&存储条件

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InS3-54 (STAT3 inhibitor)

生物&药学活性

物理化学性质&存储条件

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