Imirestat (AL-1576) | Aldose reductase inhibitor | Probechem Biochemicals

Chemical Structure : Imirestat

CAS No.: 89391-50-4

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Imirestat (AL01576, AL1576, HOE 843)

货号: PC-20625Not For Human Use, Lab Use Only.

Imirestat (AL-1576) is a potent aldose reductase inhibitor with IC50 of 8.5 nM for rat lens aldose reductase, with similar IC50 value for the human placental enzyme, shows high affinity for AKR1A1 and AKR1B1 with Ki of 47 and 46 nM respectively.

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25 mg	￥2580	In stock
50 mg	￥3980	In stock
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生物&药学活性

Imirestat (AL-1576) is a potent aldose reductase inhibitor with IC50 of 8.5 nM for rat lens aldose reductase, with similar IC50 value for the human placental enzyme, shows high affinity for AKR1A1 and AKR1B1 with Ki of 47 and 46 nM respectively.
Imirestat (AL-1576) prevents significantly the decrease of norepinephrine (NE) turnover in three tissues of streptozotocin (STZ)-diabetic rats.

物理化学性质&存储条件

分子量	286.24
分子式	C15H8F2N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,7-difluorospiro[fluorene-9,4'-imidazolidine]-2',5'-dione

参考文献

1. T T Yen, et al. Res Commun Chem Pathol Pharmacol. 1988 Aug;61(2):257-60.

2. Griffin BW, et al. Metabolism. 1987 May;36(5):486-90.

Imirestat (AL01576, AL1576, HOE 843)

生物&药学活性

物理化学性质&存储条件

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Imirestat (AL01576, AL1576, HOE 843)

生物&药学活性

物理化学性质&存储条件

参考文献

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