Imipramine Blue

Chemical Structure : Imipramine Blue

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货号: PC-61657Not For Human Use, Lab Use Only.

Imipramine Blue is a potent STAT5 inhibitor with a dual mechanism of action, potently inhibits STAT5 through liberation of endogenous phosphatase activity following NADPH oxidase (NOX) inhibition at 200-300 nM.

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生物&药学活性

Imipramine Blue is a potent STAT5 inhibitor with a dual mechanism of action, potently inhibits STAT5 through liberation of endogenous phosphatase activity following NADPH oxidase (NOX) inhibition at 200-300 nM.
Imipramine Blue effectively kills mutant FLT3-driven AML cells through a similar mechanism as thapsigargin (TG), involving increased cytosolic calcium, at 75-150 nM.
Imipramine Blue is a novel anti-invasive small molecule that inhibits invasion of glioma in vitro.

物理化学性质&存储条件

分子量	587.875
分子式	C40H51N4+
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(bis(4-(diethylamino)phenyl)methylene)-5-(3-(dimethylamino)propyl)-10,11-dihydro-2H-dibenzo[b,f]azepin-5-ium

参考文献

1. Metts J, et al. Sci Rep. 2017 Jun 30;7(1):4447.

2. Rajamanickam S, et al. Clin Cancer Res. 2016 Jul 15;22(14):3524-36.

3. Munson JM, et al. Sci Transl Med. 2012 Mar 28;4(127):127ra36.

4. Yang WH, et al. Oncogene. 2016 May 5;35(18):2287-98.

Imipramine Blue

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物理化学性质&存储条件

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Imipramine Blue

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