Imigliptin dihydrochloride |CAS:1314944-07-4 Probechem Biochemicals

Chemical Structure : Imigliptin dihydrochloride

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Imigliptin dihydrochloride (Imigliptin, KBP-3853, KBP3853)

货号: PC-60064Not For Human Use, Lab Use Only.

Imigliptin dihydrochloride (KBP-3853) is a potent, selective, orally available DPP-4 inhibitor with IC50 of 9 nM.

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生物&药学活性

Imigliptin dihydrochloride (KBP-3853) is a potent, selective, orally available DPP-4 inhibitor with IC50 of 9 nM.
Imigliptin dihydrochloride (KBP-3853) displays no activity against DPP-8 and DPP-9 (IC50>100 uM).
Imigliptin dihydrochloride (KBP-3853) shows strong effects on db/db mice in lowing glucose level, reducing AUC of oral glucose tolerance, decreasing TG and HbA1c levels, and protecting beta-cell.

物理化学性质&存储条件

分子量	449.38
分子式	C21H26Cl2N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-((7-(3-aminopiperidin-1-yl)-3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)methyl)benzonitrile dihydrochloride

参考文献

1. Shu C, et al. ACS Med Chem Lett. 2014 Jun 16;5(8):921-6.

2. Liu D, et al. Eur J Pharm Sci. 2016 Jun 30;89:73-82.

Imigliptin dihydrochloride (Imigliptin, KBP-3853, KBP3853)

生物&药学活性

物理化学性质&存储条件

参考文献

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Imigliptin dihydrochloride (Imigliptin, KBP-3853, KBP3853)

生物&药学活性

物理化学性质&存储条件

参考文献

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