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首页-小分子抑制剂&激动剂-Apoptosis-Ferroptosis-Imidazole ketone erastin
Imidazole ketone erastin

Chemical Structure : Imidazole ketone erastin

CAS No.: 1801530-11-9

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Imidazole ketone erastin (Ferroptosis inducer IKE;IKE)

货号: PC-36116Not For Human Use, Lab Use Only.

Imidazole ketone erastin (IKE, Ferroptosis inducer IKE) is a potent, metabolically stable inhibitor of system xc- and inducer of ferroptosis potentially suitable for in vivo applications.

规格 价格 库存 数量
5 mg ￥2480 In stock
10 mg ￥3880 In stock
25 mg ￥5880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Imidazole ketone erastin (IKE, Ferroptosis inducer IKE) is a potent, metabolically stable inhibitor of system xc- and inducer of ferroptosis potentially suitable for in vivo applications.
Imidazole ketone erastin (IKE) potently reduces DLBCL cell number with IC50 of <100 nM (SUDHL6 cell IC50=1 nM).
Imidazole ketone erastin (IKE) exerts antitumor effect by inhibiting system xc-, leading to glutathione depletion (GSH depletion IC50=34 nM, SUDHL6 cells), lipid peroxidation, and the induction of ferroptosis biomarkers both in vitro and in vivo, induced lipid peroxidation in tumor tissue.

物理化学性质&存储条件

分子量 655.152
分子式 C35H35ClN6O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(5-(2-(1H-imidazol-1-yl)acetyl)-2-isopropoxyphenyl)-2-((4-(2-(4-chlorophenoxy)acetyl)piperazin-1-yl)methyl)quinazolin-4(3H)-one

参考文献

1. Zhang Y, et al. Cell Chem Biol. 2019 Jan 31. pii: S2451-9456(19)30030-3.

2. Larraufie MH, et al. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4787-4792.

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