Imidazenil

Chemical Structure : Imidazenil

CAS No.: 151271-08-8

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货号: PC-38491Not For Human Use, Lab Use Only.

Imidazenil is a partial allosteric modulator of gamma-aminobutyric acid type A receptor (GABAA receptor) with anxiolytic and anticonvulsant effects, inhibits [3H] flumazenil binding to mouse cerebral cortical membranes in vitro with IC50 of 0.9 nM.

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5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
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100 mg		Get quote

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生物&药学活性

Imidazenil is a partial allosteric modulator of gamma-aminobutyric acid type A receptor (GABAA receptor) with anxiolytic and anticonvulsant effects, inhibits [3H] flumazenil binding to mouse cerebral cortical membranes in vitro with IC50 of 0.9 nM.
Imidazenil reduced in a dose-dependent manner the increase in [35S]TBPS binding elicited by isoniazid (200 mg/kg s.c.).
Imidazenil at a dose as low as 0.05 mg/kg (i.p.) delayed the onset of convulsions and death elicited by isoniazid and reduced significantly the number of mice exhibiting seizures.

物理化学性质&存储条件

分子量	399.223
分子式	C18H12BrFN4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(2-bromophenyl)-8-fluoro-4H-imidazo-[1,5-a] [1,4]benzodiazepine-3-carboxamide

参考文献

1. Giusti P, et al. J Pharmacol Exp Ther. 1993 Aug;266(2):1018-28.

2. Ghiani CA, et al. Eur J Pharmacol. 1994 Mar 21;254(3):299-302.

3. Serra M, et al. J Pharmacol Exp Ther. 1994 Apr;269(1):32-8.

Imidazenil

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物理化学性质&存储条件

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