Imetelstat | Telomerase inhibitor | Probechem Biochemicals

Chemical Structure : Imetelstat

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Imetelstat (GRN163L)

货号: PC-22757Not For Human Use, Lab Use Only.

Imetelstat (GRN163L) is a first-in-class, lipid-conjugated N3'→P5' thio-phosphoramidate oligonucleotide telomerase inhibitor with IC50 of 0.45 uM, blocks the template region of telomerase.

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生物&药学活性

Imetelstat (GRN163L) is a first-in-class, lipid-conjugated N3'→P5' thio-phosphoramidate oligonucleotide telomerase inhibitor with IC50 of 0.45 uM, blocks the template region of telomerase.

物理化学性质&存储条件

分子量	4610.18
分子式	C148H211N68O53P13S13
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[3-[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-amino-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphinothioyl]amino]-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphinothioyl]amino]-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphinothioyl]amino]-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphinoth

参考文献

1. Marian CO, et al. Clin Cancer Res. 2010 Jan 1;16(1):154-63.

2. Burchett KM, et al. PLoS One. 2014 Jan 7;9(1):e85155.

Imetelstat (GRN163L)

生物&药学活性

物理化学性质&存储条件

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Imetelstat (GRN163L)

生物&药学活性

物理化学性质&存储条件

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