Imatinib mesylate |CAS:220127-57-1 Probechem Biochemicals

Chemical Structure : Imatinib mesylate

CAS No.: 220127-57-1

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Imatinib mesylate (CGP-57148B;STI-571)

货号: PC-45914Not For Human Use, Lab Use Only.

规格	价格	库存
200 mg	￥640	In stock
500 mg	￥880	In stock
1 g	￥1280	In stock
5 g		Get quote

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生物&药学活性

Imatinib mesylate (CGP-57148B, STI-571) is a n orally bioavailability mesylate salt of Imatinib, which is a multi-kinase inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 uM, 0.1 uM and 0.1 uM in cell-free or cell-based assays.
Imatinib mesylate inhibits the SLF-dependent activation of wild-type c-kit kinase activity with IC50 of 0.1 uM.
Imatinib mesylate exhibits growth-inhibitory activity on NCI-H727 cell and BON-1 cell with IC50 of 32.4 and 32.8 uM, respectively; active in vivo.

物理化学性质&存储条件

分子量	589.7084
分子式	C30H35N7O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 49 mg/mL
Chemical Name/SMILES	Benzamide, 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-, methanesulfonate (1:1)

参考文献

1. Yao JC, et al. Clin Cancer Res. 2007, 13(1), 234-240.

2. Heinrich MC, et al. Blood. 2000, 96(3), 925-932.

3. Druker BJ, et al. Nat Med. 1996 May;2(5):561-6.

Imatinib mesylate (CGP-57148B;STI-571)

生物&药学活性

物理化学性质&存储条件

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Imatinib mesylate (CGP-57148B;STI-571)

生物&药学活性

物理化学性质&存储条件

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