Imarikiren hydrochloride |CAS:1202269-24-6 Probechem Biochemicals

Chemical Structure : Imarikiren hydrochloride

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Imarikiren hydrochloride (TAK-272;TAK 272 hydrochloride;TAK272)

货号: PC-60043Not For Human Use, Lab Use Only.

A highly potent, selective, orally active renin inhibitor with IC50 of 2.1 nM in hPRA assay.

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生物&药学活性

A highly potent, selective, orally active renin inhibitor with IC50 of 2.1 nM in hPRA assay; displays excellent selectivity against other aspartic proteases, such as pepsin and cathepsin D (IC50>10 uM); exhibits a dramatically improved PK profile in rats, and long-lasting antihypertensive efficacy in vivo.

Diabetes

Phase 2 Clinical

物理化学性质&存储条件

分子量	536.114
分子式	C27H42ClN5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-methoxybutyl)-N-(2-methylpropyl)-N-[(3S,5R)-5-(morpholin-4-yl)carbonylpiperidin-3-yl]-1H-benzimidazole-2-carboxamide hydrochloride

参考文献

1. Imaeda Y, et al. ACS Med Chem Lett. 2016 Sep 12;7(10):933-938.

Imarikiren hydrochloride (TAK-272;TAK 272 hydrochloride;TAK272)

生物&药学活性

物理化学性质&存储条件

参考文献

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Imarikiren hydrochloride (TAK-272;TAK 272 hydrochloride;TAK272)

生物&药学活性

物理化学性质&存储条件

参考文献

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